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目的分析2008-2013年泰州市疑似预防接种异常反应(Adverse Events Following Immunization,AEFI)的发生特征,评价AEFI监测系统运转情况。方法通过AEFI信息管理系统,收集2008年1月1日-2013年12月31日报告的AEFI个案数据,用描述流行病学方法进行分析。结果 2008-2013年泰州市AEFI信息管理系统共收到3 568例个案。2008-2013年全市7个市(区)每年均有AEFI报告;48 h内报告率为100%,48 h内调查率为100%。AEFI的男、女性别比为1.60∶1,≤1岁占65.89%。根据2008-2013年泰州市中国免疫规划信息管理系统疫苗接种数据估算,AEFI发生率为50.79/10万剂,异常反应发生率为4.75/10万剂。不良反应中,一般反应以发热、红肿、硬结为主,异常反应以过敏性皮疹为主。AEFI主要集中在接种后≤1 d。在所有AEFI中,治愈和好转占99.97%。结论全市AEFI监测敏感性逐年提高,AEFI监测系统运转正常。
Objective To analyze the occurrence characteristics of suspected AEFI in Taizhou City from 2008 to 2013 and evaluate the operation of AEFI monitoring system. Methods The AEFI case data collected from January 1, 2008 - December 31, 2013 were collected through the AEFI Information Management System and analyzed using descriptive epidemiological methods. Results A total of 3 568 cases were received by the AEFI information management system in Taizhou during 2008-2013. From 2008 to 2013, the city’s seven cities (districts) reported AEFI reports annually; the report rate was 100% within 48 hours and 100% within 48 hours. AEFI male and female than the ratio of 1.60:1, ≤ 1 year accounted for 65.89%. According to the vaccination data of China’s immunization program information management system in Taizhou from 2008 to 2013, the incidence of AEFI was 50.79 / 10 000 and the rate of abnormal reaction was 4.75 / 10 000. Adverse reactions, the general reaction to fever, redness, induration primarily allergic reaction to the main allergic rash. AEFI is mainly focused on ≤1 d after inoculation. Among all AEFIs, 99.97% were cured and improved. Conclusion The sensitivity of AEFI monitoring in the city is increasing year by year, and the AEFI monitoring system is in normal operation.