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血管内皮细胞生长因子(VEGF)是作用强、特异性高的血管生长因子之一,许多肿瘤均有高表达。VEGF可作为一种标志物,对肿瘤的诊断、定位靶向治疗和预后起重要作用。 1 VEGF的结构与功能 VEGF是由二硫键连接的糖蛋白二聚体,由两条-N端相同而其他区域有某些差异的多肽链组成,分子量34～43kD。不同种属VEGF的N端氨基酸序列相似但不完全相同。现知共有4种VEGF的cDNA克隆,分别编码121、165、189和206个氨基酸多肽。人VEGF基因结构有8个外显子,不同的拼接产生了不同的多肽。 VEGF是一个高度特异的血管内皮细胞有丝分裂素。现已证实血管内皮细胞因子与以前发现的血管通透性因于的核酸
Vascular endothelial cell growth factor (VEGF) is one of the strong and specific vascular growth factors, and many tumors are highly expressed. VEGF can be used as a marker for tumor diagnosis, localization of targeted therapy and prognosis play an important role. 1 The structure and function of VEGF VEGF is a disulfide-linked glycoprotein dimer composed of two polypeptide chains with the same N at the other end but with some differences in other areas, with a molecular weight of 34-43 kD. The N-terminal amino acid sequences of different species of VEGF are similar but not identical. A total of four cDNA clones of VEGF are now known, encoding 121, 165, 189 and 206 amino acid polypeptides, respectively. Human VEGF gene structure has eight exons, different splicing to produce different peptides. VEGF is a highly specific vascular endothelial cell mitogen. Vascular endothelial cytokines have been demonstrated to be associated with previously found vascular permeability due to nucleic acids