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哮喘是一种常见的慢性过敏性肺疾病,从上世纪80年代起逐渐开始流行,多见于青少年甚至涉及婴幼儿,这也引起了世界各国学者的关注。近年来,随着现代免疫学、分子生物学等学科的迅速发展,对哮喘的发病机制、病理生理、临床诊断、治疗和预防等方面有了新认识,提出许多新概念和观点,针对哮喘的研究得到飞速发展。如“细胞因子假说”和“维生素D假说”等。笔者将从以上两种假说入手,通过对哮喘特别是婴幼儿支气管哮喘的作用上来介绍1,25(OH)2D3以及IL-4的免疫调节作用及其机制,了解他们在免疫调节中的作用和地位,并进一步认识哮喘和其他变应性疾病的发病机制,为寻找解决这些疾病的新治疗方法提供新的思路。
Asthma is a common chronic allergic lung disease, which has been prevailing since the 1980s. It is more common in adolescents and even infants and young children. It has also attracted the attention of scholars all over the world. In recent years, with the rapid development of modern immunology, molecular biology and other disciplines, new understanding has been given to the pathogenesis, pathophysiology, clinical diagnosis, treatment and prevention of asthma, and many new concepts and opinions have been proposed for asthma Research has been rapidly developed. Such as “cytokine hypothesis ” and “vitamin D hypothesis ” and so on. Starting from the above two hypotheses, I will introduce the role of immune regulation of 1,25 (OH) 2D3 and IL-4 and its mechanism through the role of asthma, especially infant bronchial asthma to understand their role in immune regulation and Status and further understanding of the pathogenesis of asthma and other allergic diseases in order to find new solutions to these diseases to provide new ideas.