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目的探讨伽玛刀序贯化疗治疗非小细胞肺癌并发肺不张的临床疗效。方法回顾性分析2012~2014年解放军117医院伽玛刀治疗研究中心收治的86例并发肺不张的非小细胞肺癌患者,根据治疗方案不同,分为试验组与对照组各43例,试验组患者采用伽玛刀放疗序贯吉西他滨+顺铂(GP)化疗,对照组患者仅采用伽玛刀放疗。比较两组患者的肺复张率、不良反应发生率的差异。结果试验组患者的远期肺复张率明显高于对照组(88.3%vs 76.7%,P<0.05),试验组患者血液学毒性反应的发生率较对照组增高(58.1%vs 30.2%,P<0.05),但采用对症治疗后均可缓解。结论伽玛刀放疗序贯化疗治疗非小细胞肺癌并发肺不张效果显著,不良反应可以耐受,值得进一步研究。
Objective To investigate the clinical efficacy of gamma knife sequential chemotherapy in the treatment of non-small cell lung cancer with atelectasis. Methods A retrospective analysis of 86 patients with non-small cell lung cancer complicated with atelectasis admitted to the Gamma Knife Treatment and Research Center, 117 Hospital of PLA from 2012 to 2014 was divided into experimental group and control group (43 cases each) Patients treated with gamma knife radiotherapy sequential gemcitabine + cisplatin (GP) chemotherapy, the control group of patients treated with gamma knife radiotherapy. The differences of lung recovery rate and incidence of adverse reactions between the two groups were compared. Results The long-term pulmonary recanalization rate in the experimental group was significantly higher than that in the control group (88.3% vs 76.7%, P <0.05). The incidence of hematologic toxicities in the experimental group was significantly higher than that in the control group (58.1% vs 30.2%, P <0.05), but can be alleviated after symptomatic treatment. Conclusion Gamma Knife radiotherapy sequential chemotherapy for non-small cell lung cancer complicated with atelectasis was significant, adverse reactions can tolerate, worthy of further study.