Toll样受体在真菌性角膜炎中的调控作用

• 作 者: 王露萍
• 机 构: 山东大学齐鲁医院眼科,济南,250012
• 出 处: 中华实验眼科杂志
• 发表日期: 2015年10期
• 关键词: Keratitis fungal Toll-like receptors Signal transduction Nod-like receptors Dect

真菌性角膜炎(FK)是一种严重的致盲眼病,而Toll样受体(TLRs)在哺乳动物识别真菌的过程中发挥重要作用.大量证据表明,TLRs启动FK的天然免疫,也参与机体针对真菌的获得性免疫反应.本文探讨了TLRs与非TLRs信号通路的相互作用、TLRs信号通路的负性调节因子及TLRs在角膜真菌感染中的作用,以期为角膜真菌感染的治疗提供新的策略.“,”Fungal keratitis (FK) ,a potential blinding disease,has been difficult to treat due to the limited number of approved antifungal drugs and the taxing dosing regimen.Toll-like receptors (TLRs) function as the pattern recognition receptors (PRRs) in mammals and play an essential role in the recognition of fungal components.There is a great amount of evidence that TLRs initiate the innate immunity in the FK.Furthermore, TLRs also play roles in shaping fungal-specific humoral and cellular adaptive immune responses.This review described the recent advances in interaction between TLRs and non-TLRs signal transduction,negative regulator and function of TLRs in corneal fungal infection.