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目的：探讨去甲斑蝥素致大鼠失控炎症在多脏器功能失常综合征（ＭＯＤＳ）发病中的作用。方法：将去甲斑蝥素（一种能刺激皮肤发泡以收集巨噬细胞的致炎物质，１５ｍｇ／ｋｇ）注入６０只Ｗｉｓｔａｒ大白鼠腹腔，动态观察其对炎性介质以及器官形态和功能的影响。结果：与对照组比较，实验组动脉血氧分压（ＰａＯ２）和血小板计数明显下降，谷丙转氨酶（ＧＰＴ）和血肌酐（ＳＣｒ）明显升高，１２０小时后上述指标均接近对照组；１２小时和２４小时大鼠死亡率分别为１５％和２０％；肿瘤坏死因子（ＴＮＦ）和磷脂酶Ａ２（ＰＬＡ２）在注射后２４小时和１２小时达最高值；肺、心、肝、肾、肠等器官出现病理改变。结论：去甲斑蝥素可能通过激活巨噬细胞、释放ＴＮＦ等炎性介质诱发全身炎症和ＭＯＤＳ。
Objective: To investigate the role of norcantharidin-induced loss of control of inflammation in the pathogenesis of multiple organ dysfunction syndrome (MODS). Methods: Norcantharidin (an inflammatory substance that stimulates skin foaming to collect macrophages, 15mg / kg) was injected into the peritoneal cavity of 60 Wistar rats to observe its effects on inflammatory mediators and the morphology and function of organs influences. Results: Compared with the control group, the PaO2 and platelet count of the experimental group were significantly decreased, and GPT and SCr were significantly increased. These indexes were all close to the control group after 120 hours; Hour and 24 hour rat mortality rates were 15% and 20%, respectively. Tumor necrosis factor (TNF) and phospholipase A2 (PLA2) reached the maximum at 24 and 12 hours after injection. The rates of lung, heart, liver, kidney, Other organs appear pathological changes. Conclusion: Norcantharidin may induce systemic inflammation and MODS by activating macrophages and releasing inflammatory mediators such as TNF.