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吡哌酸(Pipemidic acid)是一种新型全合成的广谱抗菌药物。本品系白色或浅黄色结晶,对光、热、湿气,酸稳定。难溶于有机溶剂,易溶于乙酸和氢氧化钠的水溶液中。抗菌作用吡哌酸对大肠杆菌、痢疾杆菌、变形杆菌、绿脓杆菌等革兰氏阴性杆菌和部分革兰氏阳性细菌有较强的抗菌作用。它对革兰氏阴性菌的最低抑菌浓度为1.56～6.25微克/毫升。吡哌酸除有杀菌作用外,能阻抑耐药因子(R 因子)的传递。它与其他抗菌素没有交叉耐药性,与庆大霉素、羧苄青霉素对绿脓杆菌有协同作用。体内代谢口服吡哌酸吸收良好。口服后1～2小时血液浓度即达高峰,6～8小时后开始下降。本品除脑和脊髓外能广泛分布于全身,组织浓度较血浓度高,其中在泌尿道的浓度最高;在体内几乎不被代
Pipemidic acid is a new, fully synthetic, broad-spectrum antibacterial drug. This product is white or light yellow crystal, light, heat, moisture, acid stability. Insoluble in organic solvents, soluble in water and acetic acid and sodium hydroxide solution. Antimicrobial effects Pipemidic acid against Escherichia coli, Shigella, Proteus, Pseudomonas aeruginosa and other Gram-negative bacilli and some Gram-positive bacteria have a strong antibacterial effect. Its minimum inhibitory concentration of Gram-negative bacteria 1.56 ~ 6.25 micrograms / ml. Pipemidic acid in addition to sterilization, can inhibit the transmission of drug resistance factor (R factor). It is not cross-resistant with other antibiotics, and gentamicin, carbenicillin have a synergistic effect on Pseudomonas aeruginosa. In vivo metabolism of oral absorption of pipemidic acid good. 1 to 2 hours after oral administration of blood concentration reached its peak, 6 to 8 hours after the start of decline. This product in addition to the brain and spinal cord can be widely distributed in the body, the tissue concentration higher than the blood concentration, of which the highest concentration in the urinary tract; almost in the body by generation