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目的 探讨影响我国子宫颈癌高发区人乳头瘤病毒感染的因素 ,为人乳头瘤病毒感染和子宫颈癌的防治工作提供依据。方法 采用横断面调查法对山西省阳城县子宫颈癌筛查结果进行比较研究。将采集的子宫颈细胞应用第二代杂交捕获试验进行 HPV DNA检测 ,可检测 13种高危型 HPV脱氧核糖核酸 (DNA) ,以≥ 2 .0 pg/ ml作为阳性指标。资料应用 VFP软件进行录入和整理 ,用χ2 检验和非条件 L ogistic回归模型分析危险因素与子宫颈癌的关系。结果 32 33名完成了调查表和 HPV检测的妇女符合本次研究的要求 ,各性生活持续年龄段 HPV感染率差别无显著性 (χ2 =6 .35 ,P=0 .5 0 )。单因素分析显示与 HPV感染相关的因素有婚外性行为、结婚次数 (>1/ 1)、子宫颈糜烂、息肉、尿路感染和阴道滴虫 ,OR分别为 1.6 9(1.38～ 2 .0 6 )、1.6 6 (1.19～ 2 .31)、1.4 1(1.0 8～ 1.84 )、1.2 4 (1.0 5～ 1.4 6 )、1.5 7(1.2 0～ 2 .0 7)、1.2 6 (1.0 4～ 1.5 2 )。 HPV感染的危险度比值比随性伴侣数增高呈增高趋势 ,与 1个性伴侣相比 ,2、3和 >3个的危险度比值比分别为 1.37(1.0 8～ 1.74 )、1.5 5 (1.0 3～ 2 .34)和 1.6 6 (1.19～2 .31)。多因素非条件 L ogistic回归分析结果表明 ,婚外性行为和尿路感染与 HPV感染差异有显著性
Objective To explore the factors that affect the human papillomavirus infection in high incidence areas of cervical cancer in our country and provide evidence for the prevention and treatment of human papillomavirus infection and cervical cancer. Methods The cross-sectional investigation was used to compare the screening results of cervical cancer in Yangcheng County of Shanxi Province. The collected cervical cells were tested for HPV DNA using the second-generation hybridization capture test, which detected 13 high-risk HPV DNA samples with a positive rate of ≥ 2.0 pg / ml. The data were input and sorted by VFP software. The relationship between risk factors and cervical cancer was analyzed by χ2 test and non-conditional L ogistic regression model. Results 32 33 women who completed the questionnaire and HPV test met the requirements of this study. There was no significant difference in the HPV infection rate among the consecutive sex life years (χ2 = 6.35, P = .50). Univariate analysis showed that the factors related to HPV infection were extramarital sex, number of marriages (> 1/1), cervical erosion, polyp, urinary tract infection and vaginal trichomoniasis, OR were 1.6 9 (1.38-2.0 1.6 6 1.19 ~ 2.31, 1.4 1 1.08 ~ 1.84, 1.2 4 1.05 ~ 1.4 6, 1.5 7 1.2 ~ 2.07, 1.2 6 1.0 ~ 1.5 2). The risk ratio of HPV infection tended to increase with the number of sexual partners. Compared with one sexual partner, the odds ratios of 2, 3 and 3 were 1.37 (1.08-1.74), 1.55 (1.03 ~ 2.34) and 1.6 6 (1.19 ~ 2.31). Multivariate non-conditional L ogistic regression analysis showed that extra-marital sex and urinary tract infection and HPV infection were significantly different