Synthesis and cytotoxic activity of heterocycle-substituted phthalimide derivatives

• 出 处: Chinese Chemical Letters
• 发表日期: 2010年08期
• 关键词: cytotoxic substituted heterocyclic diverse pyrazole pyridine derivative furan ri

A series of heterocycle-substituted phthalimide derivatives were synthesized.Structurally diverse derivatives with heterocyclic rings,including furan,imidazo[1,2-a]pyridine,1,3,4-thiadiazine,imidazo[2,1-b][1,3,4]thiadiazine,pyrazole,1,2,4-triazolo[3,4- b][1,3,4]thiadiazine,thiazole and thiazoline,were obtained by the reactions ofα-bromoketone intermediate with various nucleophiles containing oxygen,nitrogen and sulfur atom.Their cytotoxic activity was also evaluated against five human cancer cell lines in vitro.

A series of heterocycle-substituted phthalimide derivatives were synthesized.Structurally diverse derivatives with heterocyclic rings including furan, imidazo [1,2-a] pyridine, 1,3,4-thiadiazine, imidazo [ 3,4] thiadiazine, thiazole and thiazoline, were obtained by the reactions of [alpha] -broketetone intermediate with various nucleophiles containing oxygen, nitrogen and sulfur atom. their cytotoxic activity was also evaluated against five human cancer cell lines in vitro.