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甲状旁腺疾病时,常有胃肠病表现,其发生除与甲状旁腺素(pTH)有关外,主要由钙磷代谢紊乱所致。甲旁减甲状旁腺具有很大的储备能力,一般不容易引起功能减退。由于手术、循环障碍、出血、感染及放射治疗等使甲状旁腺受到损伤后,或有甲状旁腺的变性或脂肪性变,当pTH分泌量减少到正常人的50%以下时,则可引起甲状旁腺功能减退,产生一系列的临床症状。甲旁减时pTH分泌不足,肾脏合成1,25-(OH)_2-D_3减少,引起肠与骨吸收钙减少,导致低钙血症。甲旁减时磷排泄减少,因此,多数病人呈血磷增高,后者又进一步加重低血钙。血钙降低,
Parathyroid disease, often gastrointestinal disease performance, its occurrence in addition to parathyroid hormone (pTH) related, mainly due to disorders of metabolism of calcium and phosphorus. Parathyroid parathyroid parathyroid has a great reserve capacity, generally not easy to cause dysfunction. Due to surgery, circulatory disorders, bleeding, infection and radiation therapy, etc., after the parathyroid injury, or parathyroid degeneration or fatty changes, when the pTH secretion decreased to less than 50% of normal, it can cause Parathyroid hypofunction, resulting in a series of clinical symptoms. A hypothyroidism pTH secretion, renal synthesis 1,25- (OH) _2-D_3 reduction, causing intestinal and bone resorption of calcium decreased, leading to hypocalcemia. A decrease in phosphorus excretion decreased, therefore, most patients showed increased blood phosphorus, which further aggravate hypocalcemia. Blood calcium decreased,