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目的研究不同免疫状态下，白念珠菌在小鼠肠道增殖及播散的情况。方法给经口饲白念珠菌液的小鼠口服庆大霉素、甲硝唑，腹腔注射环磷酰胺、氨甲蝶呤等处理，持续３～４周，此间每隔１周处死数只小鼠，检查其盲肠及内脏器官的白念珠菌菌落数。结果某些抗生素和免疫抑制剂处理能增加小鼠肠道内白念珠菌定居数量（Ｐ＜０．０１）；两类药物联合应用时，作用更为显著，并可使白念珠菌向内脏播散，甚或致死。结论宿主肠道白念珠菌数量以及机体免疫状态是发生播散性白念珠菌感染的重要因素
Objective To study the proliferation and dissemination of Candida albicans in mouse intestine under different immunological conditions. Methods Mice fed with Candida albicans orally were treated with gentamicin, metronidazole, cyclophosphamide and methotrexate intraperitoneally for 3 to 4 weeks. The mice were killed only once every 1 week Rats, check the number of Candida albicans colonies of the cecum and internal organs. Results Some antibiotics and immunosuppressive agents could increase the colonization of Candida albicans in the intestine of mice (P <0.01). When combined with the two drugs, the effect was more pronounced and the Candida albicans spread to the viscera , Or even lethal. Conclusions The number of host intestinal Candida albicans and the immune status are the important factors for the occurrence of disseminated Candida albicans infection