论文部分内容阅读
[目的]观察参麦注射液联合西药治疗气虚血瘀糖尿病肾病疗效。[方骞]使用随机平行对照方法,将68例住院患者按掷骰子法简单随机分为两组。对照组34例低蛋白糖尿病饮食,口服药物控制血糖,控制在5.6~7.1mmool/L,餐后血糖<11.1mmol/L,钙离子拮抗剂或β受体阻滞剂等控制血压<130/80mmHg;前列地尔10ug+0.9%生理盐水100mL,静滴,1次/d。治疗组34例参麦注射液40mL+0.9%生理盐水250mL,静滴,1次/d;西药治疗同对照组。连续治疗14d为1疗程。观测临床症状、甘油三酯、总胆固醇、血肌酐、尿素氮、尿蛋白排泄率、不良反应。治疗1疗程,判定疗效。[结果]治疗组显效13例,有效19例,无效2例,总有效率94.12%;对照组显效6例,有效19例,无效9例,总有效率73.53%;治疗组疗效优于对照组(P<0.05)。两组症状积分均有改善(P<0.01),治疗组改善优于对照组(P<0.01)。Scr、BUN、UAER两组均有改善(P<0.01),治疗组改善优于对照组(P<0.01);TG、TC治疗组均明显改善(P<0.05),对照组无明显变化(P>0.05)。[结论]参麦注射液联合西药治疗气虚血瘀糖尿病肾病疗效满意,无严重不良反应,值得推广。
[Objective] To observe the curative effect of Shenmai injection combined with Western medicine on diabetic nephropathy with Qi deficiency and blood stasis. [Fang Qian] Using randomized parallel control method, 68 inpatients were randomly divided into two groups according to the dice method. Control group, 34 cases of low-protein diet, oral control of blood glucose control in 5.6 ~ 7.1mmool / L, postprandial blood glucose <11.1mmol / L, calcium antagonists or β-blockers and other control blood pressure <130 / 80mmHg ; Alprostadil 10ug + 0.9% saline 100mL, intravenous infusion, 1 time / d. Treatment group, 34 cases of Shenmai injection 40mL + 0.9% saline 250mL, intravenous infusion, 1 / d; western medicine treatment with the control group. Continuous treatment 14d for a course of treatment. Clinical symptoms, triglycerides, total cholesterol, serum creatinine, urea nitrogen, urine protein excretion rate, adverse reactions were observed. Treatment of a course of treatment to determine the efficacy. [Results] In the treatment group, 13 cases were markedly effective, 19 cases were effective, 2 cases were ineffective and the total effective rate was 94.12%. In the control group, 6 cases were markedly effective, 19 cases were effective, 9 cases were ineffective and the total effective rate was 73.53% (P <0.05). The symptom score of both groups improved (P <0.01), and the treatment group improved better than the control group (P <0.01). The levels of Scr, BUN and UAER in both groups were improved (P <0.01), and the improvement in the treatment group was better than that in the control group (P <0.01); the levels in TG and TC groups were significantly improved (P <0.05) > 0.05). [Conclusion] Shenmai injection combined with Western medicine in treating diabetic nephropathy with Qi deficiency and blood stasis has satisfactory curative effect and no serious adverse reactions, which deserves promotion.