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了解长期接触低浓度二硫化碳（ＣＳ２）对机体铜、锌水平的影响。方法ＳＤ大鼠４８只随机分为三组，两个接触组分别吸入浓度为５ｍｇ／ｍ３和５０ｍｇ／ｍ３的ＣＳ２，每日５小时，每周６日，连续６个月。对照组吸自然空气。三组各在染毒前及染毒２、４和６个月时测血及肝铜、锌水平。结果５０ｍｇ／ｍ３ＣＳ２接触组在染毒６个月时血浆和肝脏铜水平显著降低（Ｐ＜０．０５），而５ｍｇ／ｍ３ＣＳ２接触组血浆及肝脏铜、锌水平均无显著性改变。结论长期接触ＣＳ２能干扰机体铜代谢，引起体内铜水平的降低；现行的生产车间空气中ＣＳ２最高容许浓度（１０ｍｇ／ｍ３）不会引起机体铜、锌代谢障碍。
To understand the long-term exposure to low concentrations of carbon disulfide (CS2) on the body copper, zinc levels. Methods Forty-eight Sprague-Dawley rats were randomly divided into three groups: CS2 at 5mg / m3 and 50mg / m3 were inhaled twice daily for 6 consecutive days for 6 consecutive days. The control group inhaled natural air. Three groups were tested before exposure to and 2,4,4 and 6 months of exposure to blood and liver copper, zinc levels. Results Plasma and liver copper levels in 50 mg / m3CS2 exposure group were significantly decreased at 6 months (P <0.05), while there were no significant changes in plasma and liver copper and zinc levels at 5 mg / m3 CS2 exposure. Conclusion Long-term exposure to CS2 can interfere with the metabolism of copper in the body and lead to the decrease of copper level in the body. The highest allowable concentration of CS2 (10mg / m3) in the air of the current workshop does not cause copper and zinc metabolism disorders.