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白介素13(interleukin-13,即IL-13)主要由活化的T细胞(小鼠为 Th_2)产生。IL-13对单核(巨噬细胞)、B淋巴细胞、NK细胞和血管内皮细胞等具有多种生物学作用。如抑制炎症性细胞因子产生,参与应变性疾病病理过程,调节机体的免疫功能。本文就近年来国外对IL—13研究作一综述。1 IL-13的分子生物学特点 IL—13主要由激活的T细胞分泌,尽管IL—13常常被认为是Th2型细胞因子,但迄今仍没有充分的依据支持这一结论。Zurawski等认为产生IL-13的T细胞具有ThO、
Interleukin-13 (IL-13) is mainly produced by activated T cells (mouse is Th2). IL-13 has a variety of biological effects on monocytes (macrophages), B lymphocytes, NK cells and vascular endothelial cells. Such as inhibiting the production of inflammatory cytokines, involved in the pathological process of the disease, regulate the body’s immune function. This article reviews IL-13 research abroad in recent years. 1 The molecular characteristics of IL-13 IL-13 is mainly secreted by activated T cells. Although IL-13 is often thought to be a Th2-type cytokine, so far there is not enough evidence to support this conclusion. Zurawski et al. Conclude that T-cells producing IL-13 have ThO,