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目的:探讨胰岛素生长因子-Ⅱ(IGF-Ⅱ)与胎儿宫内生长的关系及其在胎儿宫内生长迟缓(IUGR)发病中的作用。方法:选取20例分娩IUGR儿、10例分娩巨大儿及20例分娩正常儿的产妇,分娩后抽取母静脉血及脐静脉血,分离血清。用放射免疫法(RIA)测定血清中IGF-Ⅱ的浓度。结果:①母血中IGF-Ⅱ浓度显著高于脐血的IGF-Ⅱ浓度(P<0.01),且二者之间无相关性(r=0.19,P>0.05)。②脐血中IGF-Ⅱ的浓度在IUGR组明显低于对照组(P0.05),脐血IGF-Ⅱ的浓度与新生儿体重及胎盘重量呈明显的正相关关系(r=0.51和r=0.59,P<0.01)。③各组母静脉血中IGF-Ⅱ的浓度间无明显差异(P>0.05)。结论:①母血及脐血IGF-Ⅱ的来源不同,其不能通过胎盘屏障。②胎儿自身分泌的IGF-Ⅱ与胎儿生长关系密切,其浓度降低可能是导致IUGR的重要原因之一。
Objective: To investigate the relationship between insulin growth factor-Ⅱ (IGF-Ⅱ) and intrauterine growth and its role in the pathogenesis of intrauterine growth retardation (IUGR). Methods: 20 cases of IUGR childbirth, 10 cases of giant childbirth and 20 cases of normal childbirth were selected. After delivery, maternal venous blood and umbilical vein blood were collected and the serum was separated. Serum IGF-II concentrations were measured by radioimmunoassay (RIA). Results: (1) IGF-Ⅱ in maternal blood was significantly higher than that in umbilical cord blood (P <0.01), and there was no correlation between them (r = 0.19, P> 0.05). ② The concentration of IGF-Ⅱ in umbilical cord blood in IUGR group was significantly lower than that in control group (P <0.01), but there was no significant difference between giant group and control group (P> 0.05) There was a significant positive correlation between concentration and weight of newborn and placental weight (r = 0.51 and r = 0.59, P <0.01). ③ There was no significant difference in the concentrations of IGF-Ⅱ between the two groups (P> 0.05). Conclusion: ① The sources of IGF-Ⅱ in maternal and umbilical blood can not pass the placental barrier. ② Fetal self-secreting IGF-Ⅱ and fetal growth are closely related, the lower concentration may be one of the important reasons leading to IUGR.