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目的:分析重症患者丙戊酸钠血药浓度降低的原因,为心肺复苏术后抽搐患者调整个体化给药方案提供参考。方法:结合患者病理生理实际情况,根据丙戊酸钠血药浓度影响因素逐一分析,找出其血药浓度降低原因。结果:该重症患者丙戊酸钠血药浓度降低与胃肠道吸收功能差以及药物剂型生物利用度的影响有关。结论:丙戊酸钠在重症患者使用中,临床药师应发挥专业优势,协助医生综合考虑各方面的影响因素,实行个体化给药,即不仅以血药浓度为依据,还应参考病理情况等个体差异以及药物间的相互作用调整药物剂型、用法用量,以确保患者的用药安全和疗效。
OBJECTIVE: To analyze the reason of lowering plasma sodium valproate concentration in critically ill patients, and to provide reference for adjusting individualized dosing regimen in patients with tics after cardiopulmonary resuscitation. Methods: According to the actual situation of patients with pathophysiology, according to the analysis of the influencing factors of plasma concentration of valproate one by one to find out the reasons for the reduction of plasma concentration. Results: The reduction of plasma valproate concentration in this critically ill patient was associated with poor gastrointestinal absorption and bioavailability of the drug formulation. Conclusion: Sodium valproate in the use of critically ill patients, clinical pharmacists should play a professional advantage to help physicians consider all aspects of the impact of factors, the implementation of individualized administration, that is not only based on plasma concentration, but also with reference to pathological conditions Individual differences and the interaction between drugs to adjust the drug dosage form, usage and dosage to ensure the patient’s medication safety and efficacy.