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目的：研究ＮＯ在几种硝酸酯类药物的体内作用中的地位。方法：用自旋捕集－ ＥＳＲ法，测定了４ 种硝基类药物作用小鼠体内外不同组织和尿液中一氧化氮（ＮＯ） 含量的变化。结果：硝普钠，硝酸甘油和消心痛作用后，小鼠体内外ＮＯ均有不同程度的升高，而硝苯地平则未表现出ＮＯ改变。结论：由此表明，上述４ 种药物在小鼠体内的作用机制是不同的
Aims: To investigate the role of nitric oxide in the in vivo effects of several nitrates. Methods: The changes of nitric oxide (NO) content in different tissues and urine of four kinds of mice treated with four kinds of nitro drugs were measured by spin-trap-ESR method. Results: After sodium nitroprusside, nitroglycerin and antihypertensive effect, the levels of NO were increased in vivo and in vivo, while NO was not observed in nifedipine. Conclusion: This shows that the four drugs in vivo mechanism of action is different