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近年来,绿脓杆菌引起的传染病发病率在不断增长.临床医生认为,这种感染很难治疗,这是因为病原体对抗生素产生耐药性以及常常因免疫保护力低下而发生。有资料表明,超免疫血浆及特异性人和动物的免疫球蛋白含有各种绿脓杆菌抗原的抗体,并由绿脓杆菌引起动物感染的试验中证明它们的保护作用。也已证明市售的丙种球蛋白具有被动保护小鼠免于致死感染。然而,人们知道,市售的丙种球蛋白中基本上为 IgG,而正常的抗细菌抗体则主要与 IgM 组分相关。通过正常人血清组分抗体分布研究表明,抗绿脓杆菌抗体主要浓缩于 IgM 组分。
In recent years, the incidence of infectious diseases caused by Pseudomonas aeruginosa has been on the rise, and clinicians believe it is hard to treat because pathogens are resistant to antibiotics and often occur due to low immunoprotective power. It has been shown that hyperimmune plasma and specific human and animal immunoglobulins contain antibodies against various Pseudomonas aeruginosa antigens and their protective effect was demonstrated in experiments in which P. aeruginosa causes animal infections. Commercially available gamma globulin has also been shown to passively protect mice from lethal infections. However, it is known that commercially available gamma globulin is essentially IgG, whereas normal anti-bacterial antibodies are mainly associated with IgM components. Antibody distribution studies by normal human serum components showed that anti-Pseudomonas aeruginosa antibodies were mainly concentrated in IgM components.