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目的分析血清脂联素及胱抑素C在糖尿病肾病早期诊断中的价值。方法选取糖尿病患者组85例作为观察对象,并根据尿蛋白排泄率分为三组:正常蛋白尿组,微量蛋白尿组及临床蛋白尿组,同时选择健康体检者30例作为正常对照组。采用酶联免疫吸附试验(ELISA)检测血清脂联素水平,免疫比浊法检测血清胱抑素。结果糖尿病组血清脂联素及胱抑素水平明显低于正常对照组(P<0.05),而随尿蛋白排泄率的增加,血清脂联素及胱抑素水平逐渐增高(P<0.05),且血清脂联素与胱抑素呈正相关关系(r=0.652,P<0.05)。结论糖尿病患者血清APN水平的升高预示肾功能的减退,可用于糖尿病肾病的早期诊断。
Objective To analyze the value of serum adiponectin and cystatin C in the early diagnosis of diabetic nephropathy. Methods Eighty diabetic patients were selected as observation objects and divided into three groups according to urinary protein excretion rate: normal proteinuria group, microalbuminuria group and clinical proteinuria group. Meanwhile, 30 healthy subjects were selected as normal control group. Serum adiponectin levels were measured by enzyme-linked immunosorbent assay (ELISA) and serum cystatin was detected by immunoturbidimetry. Results Serum levels of adiponectin and cystatin in diabetic group were significantly lower than those in normal control group (P <0.05). Serum adiponectin and cystatin levels increased with the increase of urinary protein excretion rate (P <0.05) Serum adiponectin and cystatin had a positive correlation (r = 0.652, P <0.05). Conclusion The serum APN level in diabetic patients predicts the decline of renal function, which may be used for the early diagnosis of diabetic nephropathy.