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目的:观察动静结合运动对阿霉素诱导的心衰大鼠的心功能及血管紧张素Ⅱ(AngⅡ)和醛固酮(ALD)水平的影响。方法:取清洁级雌、雄SD大鼠各30只,随机分成4组,空白组(n=15)予以正常喂养,不做任何处理;模型组(n=15)予以阿霉素造心衰大鼠模型,不进行心脏康复运动;对照组(n=15)予以阿霉素造心衰大鼠模型,进行力竭运动;实验组(n=15))予以阿霉素造心衰大鼠模型,进行动静结合运动。6周后测定心功能及AngⅡ和ALD水平。结果:实验组心功能明显优于对照组及模型组(P<0.05);实验组AngⅡ、ALD明显降低(P<0.05),表明动静结合运动有更明显效果。结论:动静结合运动可改善心衰大鼠的心功能,降低Ang II及ALD水平。
Objective: To observe the effects of exercise and static exercise on cardiac function and the levels of angiotensin Ⅱ (Ang Ⅱ) and aldosterone (ALD) in rats with adriamycin-induced heart failure. Methods: Thirty male and female SD rats were randomly divided into 4 groups. The blank group (n = 15) was fed without any treatment. The model group (n = 15) Rats in control group (n = 15) were given doxorubicin to establish rat model of heart failure, and then exhaustive exercise was performed in experimental group (n = 15)). Adriamycin-induced heart failure rats Model, the combination of movement and movement. After 6 weeks, the cardiac function and AngⅡ and ALD levels were determined. Results: The cardiac function of the experimental group was significantly better than that of the control group and the model group (P <0.05). Ang Ⅱ and ALD of the experimental group were significantly decreased (P <0.05), indicating that the kinetic and motor activities were more obvious. Conclusion: The combination of exercise and static exercise can improve cardiac function in heart failure rats and decrease Ang II and ALD levels.