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本文对 G6PD 缺陷症患者及其家族进行多项血液生化及组织学方面研究。此类患者 G6PD 活力低下;G—SH 稳定性降低;遇氧化剂易形成变性珠蛋白小体,可经光镜及扫描、透射电镜观察到这一变化。G6PD 缺陷为伴性遗传性疾病,淋巴细胞染色体分析未见异常,认为本病确系基因突变所致。本工作对提高人口素质与防病均有一定指导意义。
This article conducts a number of biochemical and histological studies of G6PD-deficient patients and their families. Such patients G6PD activity is low; G-SH stability decreased; case of oxidative easy to form denatured globin bodies, can be observed by light microscopy and scanning electron microscopy of this change. G6PD defect is a companion genetic disease, lymphocyte chromosome analysis showed no abnormality, that the disease is indeed due to genetic mutations. This work has some guiding significance to improve population quality and disease prevention.