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为观察长期口服美西律对室性心律失常的疗效及其对心室功能的影响,本研究选择58例不同心脏病(冠心病、心肌病、心瓣膜病等)所致的心律失常病人,均有超过30次/小时的室性早搏或复杂性异位心律(多源性室性早搏、二联律、室性心动过速),其中58人(91%)曾平均应用过2.6种其他抗心律失常药,均由于副作用或无效而停用,10人有至少一次需心肺复苏的室性心动过速或心室颤动。口服美西律从100～200mg,2～3次/日开始,渐增至有副作用出现时(最大量500mg tid),然后逐渐减量至副作用
In order to observe the curative effect of long-term oral mexiletine on ventricular arrhythmia and its influence on ventricular function, 58 patients with arrhythmia caused by different heart diseases (coronary heart disease, cardiomyopathy, valvular heart disease, etc.) There are more than 30 beats / hour of premature ventricular contractions or complications (multi-ventricular premature beats, diplopia, ventricular tachycardia), of which 58 (91%) have applied on average 2.6 other anti- Arrhythmia drugs were discontinued due to side effects or ineffectiveness, and 10 had at least one ventricular tachycardia or ventricular fibrillation requiring cardiopulmonary resuscitation. Oral mexiletine from 100 ~ 200mg, 2 ~ 3 times / day, increasing to the side effects (maximum 500mg tid), and then gradually reduced to the side effects