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三碘甲腺原氨酸(T_3)与反T_3(reverse T_3)在周围组织特别是肝脏与肾脏中引起代谢。T_3与反T_3经单脱碘产生3,3′—二甲腺原氨酸和3,5—二甲腺原氨酸,这两种物质与末代谢的T_3及反T_3一起从尿中排出。在肝脏、T_3及反T_3和硫酸盐及葡萄糖醛酸结合,随胆汁分泌至肠道,从粪便排出。在许多情况下,如肝硬化、心肌梗塞、饥饿时,血清T_3降低而反T_3升高。这说明T_4代谢由活性(T_3)向失活(反T_3)转化。作者测定了40例晚期肾功能衰竭(慢性肾衰)患者血清总T_3、T_4和TSH浓度,特别是反T_3浓
Triiodothyronine (T_3) and anti-T_3 (reverse T_3) cause metabolism in the surrounding tissues, especially the liver and kidney. T_3 and anti-T_3 are mono-deiodinated to produce 3,3’-dimethylanine and 3,5-dimethylaminine, both of which are excreted from urine together with the end metabolized T_3 and anti-T_3. In the liver, T_3 and anti-T_3 and sulfate and glucuronic acid combined with bile secretion to the intestine, excreted from the feces. In many cases, such as cirrhosis, myocardial infarction, hunger, serum T_3 decreased and anti-T_3 increased. This shows that the metabolism of T 4 is converted from active (T 3) to inactive (anti T 3). The authors measured serum total T 3, T 4, and TSH concentrations in 40 patients with advanced renal failure (chronic renal failure), especially with anti-T 3 concentrations