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本文用ICR小鼠,在右耳下腺区皮下接种S_(180)腹水瘤细胞,作为移植瘤实验模型,随机分组后接受国产厌氧棒状杆菌菌苗(CC—7626株)及平阳霉素(PYM)联合治疗(CC于D_7、D_(13)和D_(19),瘤内注射0.6mg;PYM于D_8～D_(12)和D_(14)～D_(18),腹腔注射10mg/kg)以及对照治疗比较,以提供头颈部恶性肿瘤免疗—化疗联合应用的部分实验依据。结果提示:CC—PYM 联合治疗能产生明显的增强效应(q=1.15),抑瘤率达77.55％;且可提高小鼠肝、脾的脏器系数及腹腔巨噬细胞吞噬功能;病理检查提供了部分联合增强效应的形态学证据;7个月后仅存部分曾接受过 CC或 CC联合 PYM 治疗的小鼠,它们对第二次肿瘤接种均排斥,说明体内较长时期仍能维持抗肿瘤的伴随免疫效应。
In this study, S_180 ascites tumor cells were inoculated subcutaneously in the subacute area of the right ear with ICR mice as an experimental model of xenograft tumors. After randomization, the anaerobic coryneform bacilli (CC-7626 strain) and Pinyangmycin were received. PYM) combination therapy (CC on D_7, D_13, and D_19, intratumoral injection of 0.6 mg; PYM on D_8 to D_(12) and D_(14) to D_(18), intraperitoneal injection of 10 mg/kg) And compared with the control treatment, in order to provide head and neck malignancy chemotherapy - combined application of part of the experimental basis. The results suggest that: CC-PYM combined therapy can produce a significant enhancement effect (q = 1.15), the tumor inhibition rate of 77.55%; and can increase the mouse liver, spleen organ coefficient and peritoneal macrophage phagocytosis; pathological examination provides Morphological evidence of some of the combined enhancement effects; 7 months later, only the mice that had received CC or CC in combination with PYM were excluded from the second tumor vaccination, indicating that the antitumor activity can be maintained for a longer period in vivo Concomitant immune effects.