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近年来有关细胞表面的研究已确定复合糖类如糖蛋白、糖脂、粘多糖等是细胞表面的重要组分。细胞表面糖蛋白特性的改变将影响到细胞的生理功能。在研究药物对细胞表面糖结构的影响中PHA为很有用的工具。自Aub,J.G.于1963年发现PHA可使癌细胞凝集以来,国内外已有许多研究证实PHA可作为测量、鉴别细胞表面糖的探针。 ROOS等报道阿斯匹林在实验动物中可阻止肿瘤细胞的骨转移和肺外转移,在临床试用于癌肿的辅助治疗。为探索阿斯匹林阻止瘤细胞转移的作用是否和肿瘤细胞表面结构因受药物作用的影响而改变有关,我们引用了傅乃武、Hwang等人的分光光度测浊法来观察阿斯匹林对PHA凝聚EAC细
In recent years, studies on cell surfaces have confirmed that complex carbohydrates such as glycoproteins, glycolipids, and mucopolysaccharides are important components on the cell surface. Changes in the characteristics of cell surface glycoproteins will affect the physiological function of cells. PHA is a useful tool in studying the effect of drugs on the cell surface glycostructure. Since Aub, J.G. discovered that PHA can agglutinate cancer cells in 1963, many studies at home and abroad have confirmed that PHA can be used as a probe to measure and identify cell surface sugars. ROOS et al. reported that aspirin can prevent bone metastasis and extrapulmonary metastasis of tumor cells in experimental animals, and is clinically used for adjuvant treatment of cancer. To explore whether the role of aspirin in preventing the metastasis of tumor cells is related to changes in the surface structure of tumor cells due to the effects of drugs, we have quoted the spectrophotometric turbidity method of Fu Naiwu and Hwang et al. to observe aspirin pairs. PHA condensed EAC fine