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弓形虫的慢性感染可以导致宿主的情智和行为的改变。其机制主要包括:1)弓形虫感染对宿主神经细胞的直接损害;2)弓形虫感染导致的宿主免疫病理反应;3)弓形虫感染对神经递质的影响等,但具体作用的靶点和分子机制尚不清楚。本文对弓形虫感染所引起的情智行为异常及其发生机制研究进展进行了综述。
Chronic infection with Toxoplasma gondii can result in altered intelligence and behavior in the host. The mechanisms include: 1) direct damage of host cells by Toxoplasma gondii infection; 2) host immune pathological response caused by Toxoplasma gondii infection; 3) the effect of Toxoplasma gondii infection on neurotransmitter, but the specific target and The molecular mechanism is not clear. This review summarizes the research progress of abnormal intelligence and intellectual behaviors caused by Toxoplasma gondii infection and its mechanism.