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目的探讨肠镜喷洒联合口服吡喹酮治疗血吸虫病慢性腹泻的可行性和疗效。方法因慢性腹泻作纤维结肠镜检查证实为结直肠血吸虫病患者26例(实验组),行肠镜下喷洒0.2%吡喹酮溶液,然后口服吡喹酮片,60mg/(kg·d),连服3d,观察治疗效果,并与血吸虫病慢性腹泻患者单纯口服吡喹酮治疗(对照组)比较。结果实验组26例经肠镜喷洒并口服吡喹酮治疗1周后肠镜复查,结肠黏膜下虫卵均死亡,治愈率为100%,对照组治愈率为84.00%,差异有统计学意义(χ2=4.51404,P<0.05);实验组和对照组不良反应发生率分别为84.6%(22/26)和88.0%(22/25),差异无统计学意义(χ2=0.00 002,P>0.05)。结论肠镜下喷洒并口服吡喹酮治疗血吸虫病慢性腹泻疗程短,治愈率高,且无明显药物不良反应,未增加治疗费用,值得临床推广应用。
Objective To investigate the feasibility and efficacy of colonoscopy combined with oral praziquantel in the treatment of chronic diarrhea of schistosomiasis. Methods Twenty-six patients (experimental group) with colonic schistosomiasis diagnosed by chronic diarrhea were enrolled in this study. Colonies were treated with 0.2% praziquantel by means of colonoscopy and then treated with praziquantel (60 mg / (kg · d) Even serving 3d, to observe the therapeutic effect, and with chronic schistosomiasis patients with chronic diarrhea praziquantel treatment alone (control group) comparison. Results In the experimental group, 26 cases were colonoscopically sprayed and treated with praziquantel for 1 week. The colon and mucosal eggs were all dead, the cure rate was 100% and the control group was 84.00%, the difference was statistically significant ( χ2 = 4.51404, P <0.05). The incidences of adverse reactions in the experimental group and the control group were 84.6% (22/26) and 88.0% (22/25) respectively, with no significant difference (χ2 = 0.00002, P> 0.05 ). Conclusion Spraying and administration of praziquantel under colonoscopy for treatment of chronic diarrhea with schistosomiasis has short course of treatment, high cure rate, no obvious adverse drug reaction, no increase of treatment cost, and worthy of clinical application.