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目的 观察三联疗法 2周根治幽门螺旋杆菌 (HP)感染的消化性溃疡。方法 12 0例经尿素酶、组织学证实为HP感染的溃疡病人 ,接受潘他拉唑 40mg ,每日 1次 ,阿莫西林胶囊 0 .5g ,每日 3次 ,甲硝唑 0 .2g ,每日 3次 ,同时服 2周。停药后 4周观察临床效果、胃镜下溃疡愈合情况及HP根除率。结果 临床疼痛缓解率为 10 0 % ,溃疡愈合好转率 95 .8% ,HP根除率为 91.7% ,副作用 2 .5 %。结论 以新型质子泵抑制剂潘他拉唑为基础的三联疗法HP根除率高、疗程短、副作用小、依从性好 ,是较理想的治疗HP感染溃疡的方案。
Objective To observe the triple therapy for 2 weeks to cure H. pylori (HP) infection of peptic ulcer. Methods One hundred and twenty urethritis patients were histologically confirmed as HP-infected ulcer patients receiving pantoprazole 40 mg once daily, amoxicillin capsules 0.5 g three times daily, metronidazole 0.2 g, 3 times a day, while serving 2 weeks. Four weeks after discontinuation, the clinical effect, ulcer healing under gastroscope and HP eradication rate were observed. Results The clinical pain relief rate was 100%, healing rate of ulcer healing was 95.8%, HP eradication rate was 91.7% and side effects were 2.5%. Conclusion The new proton pump inhibitor pantoprazole-based triple therapy has high HP eradication rate, short course of treatment, low side effects and good compliance. It is an ideal treatment for HP-infected ulcer.