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抑郁症是临床常见的一类精神疾病。据世界卫生组织统计,当前各种类别抑郁症的患病率已占全球人口的3～5％。本病发病率高,给社会造成很大的经济负担。以美国为例,每年约耗资10～30亿美元,用于防治和抵消患病后带来的经费损失。三十年代,抑郁症缺乏有效的药物治疗。对重症抑郁症曾试用苯丙胺,甲基苯丙胺(methylam-phetamine)与右旋苯丙胺(dextroamphetamine)治疗。惜此类药物作用时间短暂且易形成药物依赖,终不能解除抑郁状态。五十年代后,又试用过中枢兴奋剂哌醋甲酯(methylphenidate)与米拉脱灵(pipradrol)等,均告无效。五十年代以后,单胺氧化酶抑制剂问世后,才打开了抑郁症药物治疗的新纪元。近
Depression is a common clinical type of mental illness. According to the statistics of the World Health Organization, the current prevalence of various types of depression has accounted for 3 to 5% of the global population. The high incidence of this disease, to the community caused a great financial burden. Take the United States as an example, it costs about 10 to 3 billion U.S. dollars each year to prevent and offset the loss of funds after the illness. In the 1930s, depression was lacking in effective medical treatment. Amphetamine, methylam-phetamine and dextroamphetamine have been tested on major depression. However, the short acting time of these drugs and easy to form a drug dependence, and ultimately can not lift the state of depression. After the fifties, they also tried the central stimulants methylphenidate and pipradrol, etc., were invalid. After the 1950s, monoamine oxidase inhibitors came out, opened a new era of depression drug treatment. near