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脂肪乳作为药物载体的应用Jeppsson 等将内相油滴中溶有巴比妥酸衍生物的大豆油脂肪乳,给小鼠静脉注射,发现睡眠时间与水溶液时相比较,可持续1倍半至2倍。这是因为乳剂的油滴被阻留在组织及脏器的毛细血管内,而使药物缓缓释出所致,同时还可能由于油滴可促进巴比妥酸在血液与脑之间的转运,或防止巴比妥酸与蛋白质结合及水解等原因。
Application of fat emulsion as a drug carrier Jeppsson et al. Injected intravenously to mice with soybean oil fat emulsion containing barbituric acid derivative in internal phase oil droplets, and found that the sleep time can be one and a half times as long as that in aqueous solution 2 times. This is because the oil droplets of the emulsion are trapped in the capillaries of the tissues and organs and the drug is slowly released. At the same time, it is also possible that the oil droplets promote the transport of barbituric acid between the blood and the brain , Or to prevent barbiturate and protein binding and hydrolysis and other reasons.