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目的:研究芳烃羟化酶(AHH)与吸烟在肺癌易感中的作用。方法:采用 AHH 直接测定法,检测肺癌患者40例、肺癌患者亲属26例及健康人45例血液淋巴细胞中 AHH 的诱导力。结果:①吸烟者中,肺癌患者 AHH 高、中、低诱导力者分别与不吸烟对照组相比有高度显著性差异(P<0.001,P<0.03,P<0.001)。②肺癌患者亲属(一级亲24人,二级亲2人)吸烟者中 AHH 低诱导力者与不吸烟对照组相比有增多趋势(P=0.18);不吸烟 AHH 高诱导力者同样有增多趋势(P=0.2)。结论:吸烟会引起肺癌患者体内的 AHH 诱导力明显升高,那些 AHH 高诱导力型的人,加上长期大量吸烟易患肺癌。
Objective: To study the role of aromatic hydroxylase (AHH) and smoking in lung cancer susceptibility. METHODS: AHH direct assay was used to detect the induction of AHH in lymphocytes of 40 patients with lung cancer, 26 relatives of lung cancer patients, and 45 healthy individuals. Results: 1 Among the smokers, lung cancer patients with high, medium, and low AHH induced strength were significantly higher than those in the non-smoking control group (P<0.001, P<0.03, P<0.001). 2 Relatives of AHH in patients with lung cancer (24 first-degree relatives and 2 second-degree relatives) had a tendency of lower induction force compared with non-smoking control group (P=0.18); those who did not smoke AHH also had a high induction force. Increase trend (P=0.2). Conclusion: Smoking can cause a significant increase in AHH-inducing power in patients with lung cancer. Those with high AHH-inducing power, combined with long-term smoking, are prone to lung cancer.