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作者在以前已证明80%以上的乳腺肿瘤含有1,25～二羟基维生素D受体。1,25(OH)_2D是维生素D的活性激素型,它抑制某些肿瘤细胞的增生,促进它们的分化。这种抗增生作用与存在1,25(OH)_2D受体有关。然而迄今还不清楚,乳腺癌中此受体状态的临床重要性,为此,作者做了如下研究。作者用单克隆抗体9A7γ做免疫细胞化学检查,检测了136名乳腺癌病人肿瘤组织切片中是否存在1,25(OH)_2D受体,而后分析了此
The authors have previously demonstrated that more than 80% of breast tumors contain 1,25-dihydroxyvitamin D receptors. 1,25(OH)_2D is the active hormonal form of vitamin D, which inhibits the proliferation of certain tumor cells and promotes their differentiation. This antiproliferative effect is related to the presence of 1,25(OH)2D receptors. However, the clinical significance of this receptor status in breast cancer remains unclear so far, and the authors have done the following studies. The authors used monoclonal antibody 9A7γ for immunocytochemistry to detect the presence of 1,25(OH)_2D receptors in tumor tissue sections of 136 breast cancer patients and then analyzed this.