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1. You can say goodbye to good choles?terol after just 2 hours of sittinAt the moment your butt hits the chair, calorie bing is significantly reduced and lipoprotein lipase, an enzyme that assists with the breakdown of fat, dramatically and rapidly drops too. Sitting for eight or more hours a day decreases the enzymes ability to convert bad cholesterol to good by 95 per?cent, scientists at The Ohio State University have found.