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目的探讨多囊卵巢综合征(PCOS)患者胰岛素生长因子-Ⅰ(IGF-Ⅰ)、胰岛素生长因子结合球蛋白-1(IGFBP-1)水平与肥胖、性激素、糖代谢各项指标之间的关系。方法测定31例PCOS研究组和29例健康对照组IGF-Ⅰ、IGFBP-1水平及肥胖、性激素、糖代谢各项指标,比较两组间差异;分析研究组IGF-Ⅰ、IGFBP-1水平与其他各项指标之间相关性。结果研究组IGFBP-1,性激素结合球蛋白(SHBG)低于对照组,体重指数(BMI),臀围比值(WHR),多毛评分(F-G评分),黄体生成素(LH),黄体生成素/卵泡刺激素(LH/FSH),总睾酮(T),游离睾酮(FT),雄烯二酮(A2),硫酸脱氢表雄酮(DHEAS),空腹胰岛素(FINS),胰岛素抵抗指数(HomaIR)高于对照组,差异均有显著性(P<0.001～0.05),IGF-Ⅰ,FSH,雌二醇(E2),17羟孕酮(17-OHP),泌乳素(PRL),空腹血糖(FBG)差别无显著性(P>0.05)。研究组中IGFBP-1与BMI呈负相关(r=-0.372,P<0.05),与FINS呈负相关(r=-0.481,P<0.01),与SHBG呈正相关(r=0.504,P<0.01),IGF-Ⅰ与各指标之间无明显相关性。结论 IGFBP-1与PCOS患者肥胖、空腹胰岛素水平密切相关。
Objective To investigate the relationship between the levels of insulin-like growth factor-Ⅰ (IGF-Ⅰ), insulin-like growth factor binding globulin-1 (IGFBP-1) and the indexes of obesity, sex hormones and glucose metabolism in patients with polycystic ovary syndrome (PCOS) . Methods The levels of IGF-Ⅰ and IGFBP-1 in 31 cases of PCOS and 29 healthy controls were measured, and the indexes of obesity, sex hormones and glucose metabolism were measured. The differences between the two groups were analyzed. The levels of IGF-Ⅰ and IGFBP-1 Other indicators of the correlation between. Results The levels of IGFBP-1 and SHBG in the study group were lower than those in the control group, body mass index (BMI), hip circumference ratio (WHR), hairy hair score (FG), luteinizing hormone (LH), luteinizing hormone / (LH / FSH), total testosterone (T), free testosterone (FT), androstenedione (A2), DHEAS, FINS, HomaIR (P <0.001 ~ 0.05). The levels of IGF-Ⅰ, FSH, estradiol (E2), 17-OHP, PRL, (FBG) was no significant difference (P> 0.05). There was a negative correlation between IGFBP-1 and BMI (r = -0.372, P <0.05) and negative correlation with FINS (r = -0.481, P <0.01) ), IGF-Ⅰ and no significant correlation between the indicators. Conclusion IGFBP-1 and PCOS patients are closely related to obesity and fasting insulin levels.