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目的了解宁波地区孕妇TORCH感染状况,为预防TORCH感染、降低新生儿出生缺陷发生率提供参考资料。方法采用酶联免疫吸附试验(ELISA)对1220例妊娠妇女进行TORCH-IgM及IgG抗体检测,然后采用病例-对照研究分析TORCH感染与不良妊娠的相关性。结果 TORCH的10项检测结果 ,包括TOX、RUV、CMV、HSV-Ⅰ和HSV-Ⅱ的IgM阳性率分别为2.42%,1.89%,4.26%,9.19%,2.54%,IgG阳性率分别为3.01%,65.4%,90.47%,52.86%,13.3%。本地区不良妊娠孕妇群体中TOX、RUV、CMV、HSV-Ⅰ和HSV-Ⅱ的IgM抗体阳性率分别为12.77%,10.20%,14.29%,21.28%,10.64%与对照组比较差异性显著(P<0.01)。结论宁波地区妊娠妇女HSV-Ⅰ感染率最高,其次是CMV。TORCH感染是不良妊娠结局的重要危险因素,应重视TORCH病原体感染的早期筛查和诊治。
Objective To understand the status of TORCH infection in pregnant women in Ningbo and provide references for preventing TORCH infection and reducing the incidence of neonatal birth defects. Methods TORCH-IgM and IgG antibodies were detected in 1220 pregnant women by enzyme-linked immunosorbent assay (ELISA). Then the case-control study was used to analyze the correlation between TORCH infection and adverse pregnancy. Results The positive rates of IgM of 10 TORCH test results including TOX, RUV, CMV, HSV-Ⅰ and HSV-Ⅱ were 2.42%, 1.89%, 4.26%, 9.19%, 2.54% and 3.01% , 65.4%, 90.47%, 52.86%, 13.3%. The positive rates of IgM antibodies to TOX, RUV, CMV, HSV-I and HSV-II in adverse pregnant women in this area were 12.77%, 10.20%, 14.29%, 21.28% and 10.64%, respectively <0.01). Conclusion Pregnancy women in Ningbo have the highest HSV-Ⅰ infection rate, followed by CMV. TORCH infection is an important risk factor for adverse pregnancy outcomes. Early screening and diagnosis of TORCH pathogen infection should be emphasized.