论文部分内容阅读
2.细胞钙稳态紊乱:静息状态下,细胞胞浆Ca2+浓度约为10-7mol/L,而细胞外液Ca2+浓度约为10-3mol/L,细胞内外Ca2+浓度相差10 000倍左右。细胞内Ca2+浓度的变动可作为细胞内信使影响多种钙依赖性酶的活性而改变细胞的功能状态。细胞一系列的Ca2+运转机制失调使细胞内Ca2+浓度出现非控制性增高时,则出现细胞钙稳态紊乱。从理论上判断这种钙稳态紊乱是由于①Ca2+-Mg2+-ATP酶(钙泵)活性降低,或Na2+/Ca2+交换、H+/Ca2+交换逆转,以致胞内Ca2+外流减少;②受体操纵性Ca2+通道、电压依赖性钙通道开放,细胞外Ca2+内流增加;③细胞质膜损伤,细胞外Ca2+内流增加;④线粒体等胞内钙库释放Ca2+增加等使细胞内Ca2+浓度出现非控制性升高。
2. Calcium homeostasis disorder: resting state, the cytoplasmic Ca2 + concentration of about 10-7mol / L, while extracellular fluid Ca2 + concentration of about 10-3mol / L, intracellular and extracellular Ca2 + concentration difference of about 10,000 times. Changes in intracellular Ca2 + concentrations can act as intracellular messengers that affect the activity of many calcium-dependent enzymes and alter the functional status of the cell. A series of cell dysregulation of Ca2 + transport mechanism causes a non-controlled increase of intracellular Ca2 + concentration, then the cellular calcium homeostasis appears. It is theoretically concluded that this disturbance of calcium homeostasis is due to a decrease in activity of Ca2 + -Mg2 + -ATPase (calcium pump) or reversal of exchange of Na2 + / Ca2 + and exchange of H + / Ca2 +, resulting in a decrease of intracellular Ca2 + outflow. ② Receptor-manipulated Ca2 + Channel, voltage-dependent calcium channel is open, increased extracellular Ca2 + influx; ③ cell plasma membrane damage, increased extracellular Ca2 + influx; ④ intracellular calcium stores such as mitochondria release of Ca2 + increase intracellular Ca2 concentration appears uncontrolled .