论文部分内容阅读
目的探讨儿茶酚胺在重症手足口病(HFMD)病理生理过程中的作用机制,探索重症HFMD患儿病情进展的早期预警指标。方法将山东大学齐鲁儿童医院2010年5月至2012年10月住院治疗的63例HFMD患儿分为3组:普通组(20例)、重型组(21例)、危重型组(22例),另选取同时期体检正常儿童20名为对照组。应用SPSS13.0软件对上述各组患儿儿茶酚胺浓度进行分析。结果 HFMD患儿重型组、危重型组血清去甲肾上腺素(NE)水平明显高于对照组、普通组,差异有统计学意义(P<0.05)。危重型组血清NE水平高于重型组,差异有统计学意义(P<0.05)。血清肾上腺素(E)、多巴胺(DA)水平各组比较差异无统计学意义(P>0.05)。结论重症HFMD患儿的儿茶酚胺水平以血清NE升高为主,且以危重型症升高明显,随病情进展有增高趋势,NE对HFMD病情评估具有一定的参考价值。
Objective To explore the mechanism of catecholamines in the pathophysiology of severe hand-foot-mouth disease (HFMD) and to explore the early warning index of the progress of the disease in children with severe HFMD. Methods Sixty-three children with HFMD admitted to Qilu Children’s Hospital of Shandong University from May 2010 to October 2012 were divided into three groups: general group (20 cases), severe group (21 cases) and critical group (22 cases) , While the other 20 healthy children in the same period were selected as the control group. SPSS13.0 software was used to analyze the catecholamine concentrations in the above groups. Results The levels of serum norepinephrine (NE) in HFMD children were significantly higher than those in control group and general group (P <0.05). Serum levels of NE in the critically ill group were significantly higher than those in the severe group (P <0.05). Serum adrenaline (E), dopamine (DA) levels in each group was no significant difference (P> 0.05). Conclusions Serum levels of NE increased in children with severe HFMD. The levels of NE increased significantly in critically ill patients and increased with the progression of the disease. NE may be of reference value for the assessment of HFMD.