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目的 :了解无症状临界性高血压患者是否有冠状动脉功能异常。方法 :经食管超声心动描记术研究 2 0例正常人 (正常对照组 )及 17例无症状临界性高血压患者 (临界性高血压组 )的冠状动脉血流储备 (CFR)。以潘生丁静脉注射后和静息时舒张期的最大血流速度比率 (D/R PDV)和收缩期最大血流速度比率 (D/R PSV )作为CFR指标。结果 :1两组受检者静息时的 PDV无显著性差异〔(43± 10 ) m m/s∶ (46± 8) mm /s,P >0 .0 5〕;2静脉注射潘生丁后临界性高血压组的 D/R PDV、D/R PSV较正常对照组明显减少 ,两组之间有显著性差异 (D/RPDV:2 .2 5± 0 .36∶ 2 .86± 0 .42 ,D/R PSV:2 .0 0± 0 .2 6∶ 2 .5 6± 0 .41,P<0 .0 5 )。结论 :无症状临界性高血压患者 CFR能力降低。
Objective: To understand if asymptomatic critical hypertensive patients have coronary artery dysfunction. Methods: The coronary flow reserve (CFR) in 20 normal subjects (control group) and 17 asymptomatic hypertensive patients (critical hypertensive group) were studied by transesophageal echocardiography. The ratio of D / R PDV and D / R PSV at venous dipyridamole to resting venous end diastolic pressure was used as CFR index. Results: 1 There was no significant difference in resting PDV between the two groups (43 ± 10 mm / s: (46 ± 8) mm / s, P> 0.05); 2 After the intravenous injection of dipyridamole, D / R PDV and D / R PSV in hypertension group were significantly lower than those in normal control group, with significant difference (D / RPDV: 2.525 ± 0.36: 2.86 ± 0.42 , D / R PSV: 2.000 ± 0.26: 2.56 ± 0.41, P <0.05). Conclusions: CFR is reduced in asymptomatic hypertensive patients.