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前列腺素E_1和Prostacyclin(PGI_2)输注可引起雷诺氏现象持久主观的改善,例如:发作的频数、严重性和时间均减少,手部温度上升,一些患者寒冷激发时不出现雷诺氏反应.系统性硬皮病患者的淋巴细胞与胚胎的成纤维细胞培养可破坏后者,从淋巴细胞表面洗脱的抗体可与内皮细胞起交叉反应.cAMP水平低下增加细胞的分泌、代谢、能动性和吞噬作用,因此促使作者测定环核苷酸作为该病中淋巴细胞活性的一个可能的标记,并研究静脉内输注Prostacyclin对淋巴细胞产生环核苷酸的作用.
Prostaglandin E_1 and Prostacyclin (PGI_2) infusions cause a lasting, subjective improvement in Raynaud’s phenomenon, such as frequency of attacks, reduced severity and duration, increased hand temperature, and no Raynaud’s reaction in some patients when challenged with cold. In patients with scleroderma, fibroblasts of lymphocytes and embryos are cultured to destroy the latter, and antibodies that elute from the surface of lymphocytes can cross-react with endothelial cells. The low level of cAMP increases cell secretion, metabolism, motility and phagocytosis , Prompted the authors to measure cyclic nucleotides as a possible marker of lymphocyte activity in the disease and to investigate the effect of intravenous infusion of Prostacyclin on the production of cyclic nucleotides in lymphocytes.