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核因子(nuclear factor,NF)κB是一种广泛存在于细胞内的转录因子,参与多种基因的表达和调控[1]。ICAM-1和VCAM-1基因都含有NF-κB的结合位点,是介导炎性细胞与血管内皮细胞黏附、结合的主要的黏附分子[2,3]。NF-κB的激活和表达状态的改变,可能在妊娠高血压综合征(妊高征)的发
Nuclear factor (NF) κB is a widespread intracellular transcription factor involved in the expression and regulation of a variety of genes [1]. Both the ICAM-1 and VCAM-1 genes contain a binding site for NF-κB and are the major adhesion molecules that mediate the adhesion and binding of inflammatory cells to vascular endothelial cells [2,3]. The activation of NF-κB and the change of the expression state may occur in the development of pregnancy-induced hypertension (PIH)