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1.从萱草根中提取的組分,对結核菌有强力制菌作用,其有效成分与抗血吸虫成分不同,溶于乙醚,具耐热性,故加热后可破坏其毒性成分,而保留其疗效。 2.萱Ⅲ对敏感与耐受常用抗結核药的結核菌株有同样的制菌力,制菌浓度在1:160,000～1:640,000之間,加血清后,制菌力降至原先活力的1/4。結核菌H_(37)Rv株与1:20,000浓度的萱Ⅲ接触3日后,細菌生活力与致病力显著减低,接触7日,細菌全部死亡。但同一浓度的萱Ⅲ并不引起結核菌形态的改变。 3.初步发現,萱草乙醚浸膏对豚鼠实驗性結核病,萱Ⅲ对小白鼠实驗性結核病均有减輕病变的作用,但尚不够显著。 4.未見萱Ⅲ引致实驗动物視神經萎縮和肢体瘫痪等严重毒性,且对动物的造血系統、肝、腎等脏器无毒性反应。
1. Hemerocallis root extract from the components of the strong bacteriostasis of M. tuberculosis, the active ingredient and anti-schistosome composition is different, soluble in ether, with heat resistance, so it can be destroyed after heating the toxic components, and retain its Efficacy. 2. Xuan Ⅲ susceptible and resistant to commonly used anti-TB drugs tuberculosis strains have the same bacteriostatic power, the concentration of bacteria between 1: 160,000 ~ 1: 640,000, plus serum, the bacteria reduced to the original viability of 1 / 4. The bacterial viability and virulence of M. tuberculosis H_ (37) Rv strain after exposure to 1: 20,000 concentration of Xuan Ⅲ for 3 days were significantly reduced. On the 7th day of exposure, all the bacteria died. However, the same concentration of Xuan Ⅲ does not cause the morphological changes of TB. Preliminary findings, Hemerocallin ether extract of experimental tuberculosis in guinea pigs, Xuan Ⅲ mouse experimental tuberculosis have lessened lesions, but not significant enough. 4. No Xuan III caused serious damage of optic nerve atrophy and limb paralysis in experimental animals, and no toxic reaction on animal hematopoietic system, liver, kidney and other organs.