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Objective:To evaluate the efficacy of intravitreal triam-cinolone acetonide in the managemen t of persistent mac-ular edema secondary to nonischemic central retinal vein occlusion(CRVO).Methods:Twenty consecutive pa-tients were selected with a 3-to 4-mo nth history of nonischemic CRVO and persistent mac ular edema.These patients received a single intravitreal injection of 4mg of triamcinolone acetonide(40mg /mL).The follow-up period ranged from 10to 12months.The amount of macular edema was assessed by the amo unt of retinal thickening on clinical examination using the Goldmann contact lens and by the area and inten sity of staining on fluorescein angiography.Treated p atients were compared with a retrospectively matched grou p of patients who were managed with observation only.Main Outcome Mea-sures:Changes in visual acuity and a mount of macular edema were assessed in the treated patients and com-pared with the observation group.Re sults:The mean baseline visual acuity in the treatm ent group was 20/132vs20/123for the observation group(P=.57).After 1week,the treated group had a mean vis ual acuity of 20/51.At final follow-up,the treated g roup had a mean visual acuity of 20/37while the obse rvation group had a mean visual acuity of 20/110(P=.001).Sixty per-cent of treated patients had a final v isual acuity of 20/40or better vs only 20%in the observation group(P=.01).Forty percent of the untreated pati ents had a final visual acuity worse than 20/200whil e none of the treated patients did(P<.001).At final follow-up,75%of treated patients had complete resolution of mac-ular edema on clinical examination vs only 20%of the untreated patients(P<.001).Two of the treated pa-tients had recurrence of macular edema at 6months,and3had elevated intraocular pressure.Conclusion:This study shows a treatment benefit from intravitreal triamci-nolone in terms of visual acuity and m acular edema for nonischemic CRVO.
Objective: To evaluate the efficacy of intravitreal triam-cinolone acetonide in the managemen t of persistent mac-ular edema secondary to nonischemic central retinal vein occlusion (CRVO). Methods: Twenty consecutive pa-tients were selected with a 3-to 4-mo nth history of nonischemic CRVO and persistent mac uranium edema.These patients received a single intravitrealrealm injection of 4 mg of triamcinolone acetonide (40 mg / mL). The follow-up period ranged from 10to 12months.The amount of macular edema was assessed by the amo unt of retinal thickening on clinical examination using the Goldmann contact lens and by the area and in stenosis of staining on fluorescein angiography. Terminated p atients were compared with a retrospectively matched grou p of patients who were managed with observation only. Main Outcome Mea-sures: Changes in visual acuity and a mount of macular edema were assessed in the treated patients and com-pared with the observation group. Re sults: The mean baseline visual acuity in the treatm e nt group was 20/132 vs 20/123 for the observation group (P = .57). After 1 week, the treated group had a mean vis ual acuity of 20 / 51.At final follow-up, the treated g roup had a mean visual acuity of 20 / 37while the obsevation group had a mean visual acuity of 20/110 (P = .001). Sixty per-cent of treated patients had a final v isual acuity of 20 / 40or better vs only 20% in the observation group (P = .01) .Forty percent of the untreated patints had a final visual acuity worse than 20 / 200whil e none of the treated patients did (P <.001) .At final follow-up, 75% of treated patients had complete resolution of mac-ular edema on clinical examination vs only 20% of the untreated patients (P <.001). Two of the treated pa-tients had recurrence of macular edema at 6months, and three elevated intraocular pressure. Conclusion: This study shows a treatment benefit from intravitreal triamci-nolone in terms of visual acuity and m acular edema for nonischemic CRVO.