论文部分内容阅读
最早认识SRC家族蛋白是将其作为一组与转录调控有关的蛋白辅助因子,它们发挥作用是通过与其它的核受体超家族成员的相互作用实现的。后来发现,SRC与其它转录因子的转录调控有关系,这些转录因子是不同的信号途径的重要组分,并在细胞过程的信号途径中发挥重要的作用。SRC家族成员能够和肌细胞生成素、MEF-2、转录增强子、NF-κB、AP-1、STAT、p53和E2F1等发生相互作用,这表明SRC共激活因子能参与到多个细胞代谢过程中。近来的研究表明,多种SRC蛋白的自身修饰在决定转录产物和招募特定的SRC共激活因子过程中发挥重要的作用。本文就SRC家族蛋白自身修饰的特点予以综述。
The first understanding of the SRC family of proteins is that it acts as a group of protein cofactors involved in transcriptional regulation that function through interactions with other members of the nuclear receptor superfamily. It was later discovered that SRC is involved in the transcriptional regulation of other transcription factors that are important components of different signaling pathways and play an important role in the signaling pathways of cellular processes. SRC family members can interact with myogenin, MEF-2, transcriptional enhancer, NF-κB, AP-1, STAT, p53 and E2F1 etc., indicating that SRC coactivator can participate in multiple cellular metabolic processes in. Recent studies have shown that self-modification of multiple SRC proteins plays an important role in determining transcriptional products and recruitment of specific SRC coactivators. This article reviews the characteristics of SRC family proteins self-modification.