【摘 要】
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BACKGROUND AND OBJECTIVEDepression is consistently associated with cognitive impairment and increased risk for dementia. This study was designed to better understand the association between pharmacolo
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BACKGROUND AND OBJECTIVEDepression is consistently associated with cognitive impairment and increased risk for dementia. This study was designed to better understand the association between pharmacologic treatment of depression and cognitive decline.
METHODSData for this study were derived from the nationally representative Health and Retirement Study (HRS) and the HRS Prescription Drug Study (PDS), which included serial assessments of cognitive function, depression and antidepressant treatment. Data were drawn from the 2004, 2006, 2008 and 2010 findings of the HRS and from the 2005 and 2007 findings of the PDS. Baseline depression status was determined using the 2004 wave of the HRS.
RESULTSOf the 3，714 respondents, 12% were taking antidepressant medication at baseline. No significant differences were detected in cognition scores between the patients taking antidepressants and those who were not. At six year follow-up, both users and nonusers of antidepressants had experienced a cognitive decline. Adjusted analysis revealed that cognitive decline did not differ between those taking and those not taking antidepressant medications.
CONCLUSIONThis longitudinal study of a population representative cohort of older adults found that antidepressant use is not associated with changes in cognitive function over a six-year period.
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