Hip osteoarthritis and mortality in older women

• 出 处: 中华物理医学与康复杂志
• 发表日期: 2015年37期

BACKGROUND AND OBJECTIVE

Osteoarthritis (OA) affects 27 million adults in the United States, primarily impacting the knees, hips and small joints of the hand. Those with OA are more likely than the general population to have certain comorbid conditions, including obesity, heart disease and gastrointestinal disease. This study was designed to determine the risk of all-cause and disease specific mortality among older women with hip OA.

METHODS

Data were obtained from the Study of Osteoporotic Fractures (SOF), a prospective cohort study of women 65 years of age or older, recruited from four metropolitan areas in the United States. The original cohort comprised 9，704 Caucasian women, recruited from 1986 through 1988, all able to walk without assistance. Hip radiographs were obtained at baseline and at year eight, with radiographic hip OA (RHOA) determined for each. The patients were followed for 16 years, with all deaths verified and hospital discharge summaries obtained. Twelve potential confounders related to both hip osteoarthritis and mortality were selected for consideration in multivariate models.

RESULTS

The results revealed an eight percent prevalence of RHOA at baseline, and an 11% prevalence at eight-year follow-up. RHOA was associated with an increased risk of all-cause mortality (Hazard Ratio＝1.14) and cardiovascular disease mortality (Hazard Ratio＝1.24) after adjusting for age, BMI, education, smoking status, health status, diabetes and stroke. The authors estimated that 42% of the increase in all-cause mortality and 25% of the increase in cardiovascular disease mortality could be explained by poor physical function.

CONCLUSION

This study of women 65 years of age or older found that hip osteoarthritis is an associated with an increased risk of all-cause and cardiovascular disease mortality.