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糖皮质激素(如可的松、强的松、氢化可的松、地塞米松等)类药物作用复杂,临床应用广泛,常与其他药物联合应用。为了安全、合理、有效的联合用药,现将有关资料叙述如下。一、糖皮质激素与催眠、抗癫痫、解热止痛药合用。 1、与苯巴比妥苯巴比妥为肝药酶诱导剂,能促进糖皮质激素的代谢,并抑制垂体前叶分泌促皮质激素,故可降低糖皮质激素的分泌,使血药浓度降低,作用减弱,疗效下降。
Glucocorticoids (such as cortisone, prednisone, hydrocortisone, dexamethasone, etc.) class of drugs complex role, a wide range of clinical applications, often combined with other drugs. For safe, reasonable and effective combination, the relevant information is as follows. First, glucocorticoid and hypnosis, anti-epilepsy, antipyretic analgesics combined. 1, and phenobarbital phenobarbital liver drug enzyme inducer, can promote glucocorticoid metabolism, and inhibit the anterior pituitary secretion of corticotropin, it can reduce glucocorticoid secretion, so that blood concentration decreased , Weakened role, efficacy decreased.