论文部分内容阅读
答:G6PD即是6-磷酸葡萄糖脱氢酶。人体内成熟的红细胞利用血液中的葡萄糖通过无氧酵解获得能量。在无氧酵解中产生6-磷酸葡萄糖,并进一步依靠G6PD氧化为6-磷酸葡萄糖酸,在此同时,氧化型的三磷酸吡啶核苷(NADP~+)得以还原为还原型三磷酸吡啶核苷(NADPH),而NADPH又可使氧化型谷胱甘肽(GSSG)还原为还原型谷胱甘肽(GSH)。GSH可稳定血红蛋白、膜蛋白以及膜蛋白的巯基使其免遭氧化。NADPH和GSH可使红细胞内不断形成的高铁血红蛋白还原为正常的血红蛋白。这样保持了红细胞的稳定性使其免遭破坏。伯氯喹啉等药物(代谢物)能与氧合血红蛋白作
A: G6PD is 6-phosphoglucose dehydrogenase. The body’s mature red blood cells use glucose in the blood to gain energy through anaerobic glycolysis. Phosphorylate 6-phosphate is produced during anaerobic glycolysis and is further oxidized to 6-phosphogluconate by G6PD. At the same time, an oxidized form of the nucleoside triphosphate triphosphate (NADP ~ +) is reduced to a reduced form pyridine nucleus (NADPH), which in turn reduces oxidized glutathione (GSSG) to reduced glutathione (GSH). GSH stabilizes hemoglobin, membrane proteins, and sulfhydryl groups of membrane proteins from oxidation. NADPH and GSH reduce the formation of methemoglobin in erythrocytes to normal hemoglobin. This maintains the stability of the red blood cells from being destroyed. Boolean quinoline and other drugs (metabolites) can be made with oxyhemoglobin