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目的:研究奥硝唑在碳纳米管修饰的玻碳电极上的电化学行为及其测定方法。方法:循环伏安法和线性扫描伏安法。结果:在0.2 mol.L-1NH3-NH4Cl缓冲溶液(pH9.0)和1.2 mol.L-1NaCl溶液组成的底液中,奥硝唑在-0.62 V(υs.SCE)处出现一灵敏的还原峰,2.0×10-7～3.0×10-5mol.L-1范围内呈线性关系(r=0.998),检出限为1.5×10-8mol.L-1。并用循环伏安法研究了奥硝唑还原峰的电流性质,发现电极反应是完全不可逆的,并存在一定的吸附性。结论:利用奥硝唑在碳纳米管修饰的玻碳电极上的还原行为建立的分析方法简便灵敏,结果准确可靠,可用于奥硝唑的质量监控及药代动力学研究。
Objective: To study the electrochemical behavior of ornidazole on carbon nanotubes modified glassy carbon electrode and its determination method. Methods: Cyclic voltammetry and linear sweep voltammetry. Results: A sensitive reduction of ornidazole at -0.62 V (υs.SCE) was observed in the bottom solution consisting of 0.2 mol·L-1 NH3-NH4Cl buffer solution (pH 9.0) and 1.2 mol·L-1 NaCl solution (R = 0.998) in the range of 2.0 × 10-7 ~ 3.0 × 10-5mol·L-1, the detection limit was 1.5 × 10-8mol.L-1. The current properties of ornidazole reduction peak were studied by cyclic voltammetry. It was found that the electrode reaction was completely irreversible and had some adsorption. Conclusion: The analytical method of Ornidazole based on the reduction behavior of carbon nanotubes modified glassy carbon electrode is simple and sensitive, the results are accurate and reliable, and can be used for the quality control and pharmacokinetic study of ornidazole.