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目的:研究血清瘦素水平及血清肿瘤坏死因子-α含量与非酒精性脂肪肝病的相关性,探讨腹部推拿对非酒精性脂肪肝病患者血清瘦素水平及肿瘤坏死因子-α含量的影响。方法:选择非酒精性脂肪肝患者103例作为研究对象,按随机数字表法随机分为治疗组与对照组。对照组患者在饮食、运动指导的基础上,加用水飞蓟宾葡甲胺片200mg口服,每日3次,疗程共30天。治疗组在饮食、运动指导的基础上,加用腹部推拿1次/天,疗程共30天。治疗前后测定血清瘦素水平及血清肿瘤坏死因子-α含量。结果与对照组相比,治疗组血清瘦素水平及血清肿瘤坏死因子-α含量下降明显,两组比较有统计学差异P<0.05。结论:腹部推拿治疗非酒精性脂肪肝病有效,可能是通过降低血清瘦素水平及血清肿瘤坏死因子-α含量实现的。
Objective: To study the correlation between serum leptin level, serum tumor necrosis factor-α content and non-alcoholic fatty liver disease and to explore the effect of abdominal massage on serum leptin level and tumor necrosis factor-α content in patients with non-alcoholic fatty liver disease. Methods: A total of 103 patients with non-alcoholic fatty liver were selected as study subjects and randomly divided into treatment group and control group according to random number table method. Control group patients in diet, exercise guidance, based on the addition of silybin meglumine 200mg orally, 3 times a day, a total of 30 days. The treatment group in diet, exercise guidance, plus abdominal massage 1 / day, a total of 30 days. Serum leptin levels and serum tumor necrosis factor-α levels were measured before and after treatment. Results Compared with the control group, serum leptin levels and serum tumor necrosis factor-α levels decreased significantly in the two groups, with statistical significance (P <0.05). Conclusion: Abdominal massage for the treatment of non-alcoholic fatty liver disease is effective, may be through the reduction of serum leptin levels and serum tumor necrosis factor-α content achieved.