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目的:观察贵州粗壮女贞(Ligustrum robustum BL)降血糖效果。方法:采用尾静脉注射四氧嘧啶造成小鼠糖尿病模型,观察贵州粗壮女贞降血糖作用。结果:贵州粗壮女贞低、中、高剂量组(8g.kg-1.d-1、12g.kg-1.d-1、24g.kg-1.d-1)小鼠给药后血糖值较给药前下降,差异有显著性(P<0.01);与糖尿病模型小鼠比较,粗壮女贞不同剂量组的小鼠血糖值均下降,差异有显著性(低剂量组P<0.05,中、高剂量组P<0.01);与阳性对照组比较,高剂量组小鼠血糖值与消渴丸组无差异(P>0.05)。结论:贵州粗壮女贞对糖尿病模型小鼠具有降血糖作用,高剂量的粗壮女贞降糖效果达到消渴丸的水平。
Objective: To observe the hypoglycemic effect of Ligustrum robustum BL. METHODS: The mouse model of diabetes was induced by tail vein injection of alloxan, and the hypoglycemic effect of Guizhou stract privet was observed. RESULTS: Blood glucose levels after administration in mice of low, medium and high doses (8g.kg-1.d-1, 12g.kg-1.d-1, 24g.kg-1.d-1) of Ligustrum lucidum from Guizhou The value decreased compared with that before administration, and the difference was statistically significant (P<0.01). Compared with the diabetic model mice, the blood glucose levels of the different doses of Ligustrum lucidum were decreased, the difference was significant (low dose group P<0.05, In the high-dose group (P<0.01), compared with the positive control group, the blood glucose level of the high-dose group had no difference with Xiaoke Pill group (P>0.05). Conclusion: Ligustrum lucidum from Guizhou has a hypoglycemic effect on diabetic model mice, and the effect of high-dose crude privet cerevisiae is Xiaokewan.